Research

AR-V7 in Peripheral Whole Blood of Patients with Castration-resistant Prostate Cancer: Association with Treatment-specific Outcome Under Abiraterone and Enzalutamide

Background
Androgen receptor splice variant 7 (AR-V7) expression in circulating tumor cells
(CTCs) was demonstrated to predict poor treatment response in metastatic castrationresistant
prostate cancer (mCRPC) patients treated with abiraterone or enzalutamide.
Objective
To develop a practical and robust liquid profiling approach for direct quantification of
AR-V7 in peripheral whole blood without the need of CTC capturing and to determine
its potential to predict treatment response in mCRPC patients.

Clinically relevant lot-to-lot reagent difference in a commercial immunoturbidimetric assay for glycated hemoglobin A1c

Objectives: Hemoglobin A1c (HbA1c) is employed for diagnosis and therapy monitoring of diabetes mellitus. The effect of a change of reagent lot on the measured values of a commercial immunoturbidimetric HbA1c assay (A1C3) was investigated.

Central Laboratory Service and Point-of-Care Testing in Germany - From Conflicting Notions to Complementary Understandings

Point-of-care testing (POCT) enables health care personnel to perform laboratory medicine tests near the patient. The underlying technology and the range of test parameters available are evolving rapidly. Thus, a series of clinical applications are possible that can shorten the time for clinical decision-making about additional testing or therapy, as delays are no longer caused by preparation of clinical samples, transport, and central laboratory analysis.

Subscribe to Research